Educational Resources


Time-Resolved Macromolecular Crystallography and Solution Scattering


  • Moffat, K.
    CHAPTER 5:Dynamic and Static X-ray Scattering from Biological Systems on the Femtosecond to Nanoscond Time Scale
    in X-Ray FREE ELECTRON LASERS, pp 105-127 (2017)
  • Srajer, V., and Schmidt, M.
    Watching proteins function with time-resolved x-ray crystallography.
    J. Phys. D: Appl. Phys. (2017)
  • Schmidt, M.
    Time-Resolved Macromolecular Crystallography at Modern X-Ray Sources
    in Protein Crystallography, pp 273–294. Humana Press, New York, NY. (2017)
  • Sui, S., and Perry, S. L.
    Microfluidics: From crystallization to serial time-resolved crystallography.
    Structural Dynamics 4, 032202 (2017)
  • Schotte, F., Cho, H. S., Kamikubo, H., Kataoka, M., and Anfinrud, P. A.
    Watching a Signaling Protein Function in Real Time via Picosecond Time-Resolved Laue Crystallography
    In Molecular Science of Fluctuations Toward Biological Functions (Terazima, M., Kataoka, M., Ueoka, R., and Okamoto, Y., Eds.),
    pp 65–85. Springer Japan (2015)

  • J. G. Kim, T. W. Kim, J. Kim and H. Ihee
    Protein Structural Dynamics Revealed by Time-Resolved X-ray Solution Scattering.
    Accounts of Chemical Research 48, 2200–2208 (2015)
  • M. Schmidt
    Time-Resolved Crystallography at X-ray Free Electron Lasers and Synchrotron Light Sources
    Synchrotron Radiation News 28, 25–30 (2015)
  • Keith Moffat
    Time-resolved crystallography and protein design: signalling photoreceptors and optogenetics.
    Phil. Trans. R. Soc. B 369, 20130568 (2014)
  • V. Šrajer: Time-resolved Macromolecular Crystallography in Practice at BioCARS, Advanced Photon Source: From Data Collection to Structures of Intermediates
    Published in “The Future of Dynamic Structural Science, NATO Science for Peace and Security Series A: Chemistry and Biology”
    (J.A.K. Howard, et al, Eds.), Springer Science+Business Media Dordrecht, Chapter 17, pp. 237-251 (2014)
    (The final publication is available here)
  • Zhong Ren
    Laue Data Processing with Precognition
  • M. Schmidt, V. Srajer, R. Henning, H. Ihee, N. Purwar, J. Tenboer and S. Tripathi
    Protein energy landscapes determined by five-dimensional crystallography.
    Acta Cryst. D Biological Crystallography 69, 2534–2542 (2013)
  • R. Neutze and K. Moffat
    Time-resolved structural studies at synchrotrons and X-ray free electron lasers: opportunities and challenges.
    Curr. Opin. Struct. Biol. 22, 651–659 (2012)
  • D. Bourgeois, M. Weik
    Kinetic protein crystallography: a tool to watch proteins in action
    Crystallography Reviews 15 (2) 87-118 (2009)
  • M. Schmidt
    Structure-based kinetics by time-resolved X-ray crystallography
    In Ultrashort Laser Pulses in Biology and Medicine (Markus Braun, Peter Gilch and Wolfgang Zinth, eds.), Springer Berlin Heidelberg, pp. 201-241 (2008)
  • D. Bourgeois, F. Schotte, M. Brunori, and B. Vallone
    Time-resolved methods in biophysics. 6. Time-resolved Laue crystallography as a tool to investigate photo-activated protein dynamics
    Photochem. Photobiol. Sci. 6, 1047–1056 (2007)
  • K. Moffat
    Laue Crystallography: Time Resolved Studies
    In International Tables for X-Ray Crystallography, Volume F: Crystallography of Biological Macromolecules, edited by M. G. Rossmann and E. Arnold. Ch. 8.2, p. 167-176 (2006)
    more information
  • M. Schmidt, H. Ihee, R. Pahl and V. Srajer
    Protein-ligand interactions probed by time-resolved crystallography.
    In Protein-Ligand Interactions: Methods and Applications (G. U. Nienhaus, ed.), Methods in Molecular Biology, vol. 305,
    Humana Press, Totawa, NJ, pp. 115-154 (2005)

  • D. Bourgeois and A. Royant
    Advances in kinetic protein crystallography
    Current Opinion in Structural Biology 15 (5), 538-547 (2005)
  • M. Goeldner, R. Givens, eds.
    Dynamic Studies in Biology: Phototriggers, Photoswitches and Caged Biomolecules
    Wiley-VCH, pp. 410–434 (2005)