Rimmerman, D., Leshchev, D., Hsu, D. J., Hong, J., Kosheleva, I., and Chen, L. X.  Direct Observation of Insulin Association Dynamics with Time-Resolved X-ray Scattering.  J. Phys. Chem. Lett. 4413–4418 (2017) abstract

Free-energy surfaces for insulin dissociation reaction as a result of T-jump. The red lines represent the nonequilibrium population immediately after T-jump. The yellow line shows the ensemble pathway toward dissociation as the system is driven back toward equilibrium.