Educational Resources
Time-Resolved Macromolecular Crystallography and Solution Scattering
- Malla, T. N., and Schmidt, M. Transient state measurements on proteins by time-resolved crystallography. Current Opinion in Structural Biology 74, 102376 (2022) Abstract
- Westenhoff, S., Meszaros, P., and Schmidt, M. Protein motions visualized by femtosecond time-resolved crystallography: The case of photosensory vs photosynthetic proteins. Current Opinion in Structural Biology 77, 102481 (2022) Abstract
- Schulz, E. C., Yorke, B. A., Pearson, A. R., and Mehrabi, P. Best practices for time-resolved serial synchrotron crystallography. Acta Cryst D 78, 14–29 (2022) Abstract
- Brändén, G., and Neutze, R. Advances and challenges in time-resolved macromolecular crystallography. Science 373, eaba0954 (2021) Abstract
- Monteiro, D. C. F., Amoah, E., Rogers, C., and Pearson, A. R. Using photocaging for fast time-resolved structural biology studies. Acta Crystallogr D Struct Biol 77, 1218–1232 (2021) Abstract
- Pearson, A. R., and Mehrabi, P. Serial synchrotron crystallography for time-resolved structural biology. Current Opinion in Structural Biology 65, 168–174 (2020) Abstract
- Schmidt, M. Time-Resolved Macromolecular Crystallography at Pulsed X-ray Sources. International Journal of Molecular Sciences 20, 1401 (2019) Abstract
- Moffat, K. CHAPTER 5:Dynamic and Static X-ray Scattering from Biological Systems on the Femtosecond to Nanosecond Time Scale. X-Ray FREE ELECTRON LASERS, pp 105-127 (2017) Abstract
- Srajer, V., and Schmidt, M. Watching proteins function with time-resolved x-ray crystallography. J. Phys. D: Appl. Phys. (2017) Abstract
- Schmidt, M. Time-Resolved Macromolecular Crystallography at Modern X-Ray Sources. Protein Crystallography, pp 273–294. Humana Press, New York, NY. (2017) Abstract
- Sui, S., and Perry, S. L. Microfluidics: From crystallization to serial time-resolved crystallography. Structural Dynamics 4, 032202 (2017) Abstract
- Kim, J., Kim, K. H., Oang, K. Y., Lee, J. H., Hong, K., Cho, H., Huse, N., Schoenlein, R. W., Kim, T. K., and Ihee, H. Tracking reaction dynamics in solution by pump–probe X-ray absorption spectroscopy and X-ray liquidography (solution scattering). Chem. Commun. 52, 3734–3749 (2016) Abstract
- Schotte, F., Cho, H. S., Kamikubo, H., Kataoka, M., and Anfinrud, P. A. Watching a Signaling Protein Function in Real Time via Picosecond Time-Resolved Laue Crystallography. Molecular Science of Fluctuations Toward Biological Functions (Terazima, M., Kataoka, M., Ueoka, R., and Okamoto, Y., Eds.),
pp 65–85. Springer Japan (2015) - J. G. Kim, T. W. Kim, J. Kim and H. Ihee. Protein Structural Dynamics Revealed by Time-Resolved X-ray Solution Scattering. Accounts of Chemical Research 48, 2200–2208 (2015) Abstract
- M. Schmidt. Time-Resolved Crystallography at X-ray Free Electron Lasers and Synchrotron Light Sources. Synchrotron Radiation News 28, 25–30 (2015) Abstract
- Keith Moffat. Time-resolved crystallography and protein design: signaling photoreceptors and optogenetics. Phil. Trans. R. Soc. B 369, 20130568 (2014) Abstract
- V. Šrajer: Time-resolved Macromolecular Crystallography in Practice at BioCARS, Advanced Photon Source: From Data Collection to Structures of Intermediates. The Future of Dynamic Structural Science, NATO Science for Peace and Security Series A: Chemistry and Biology (J.A.K. Howard, et al, Eds.), Springer Science+Business Media Dordrecht, Chapter 17, pp. 237-251 (2014) (Abstract)
- Zhong Ren. Laue Data Processing with Precognition
- M. Schmidt, V. Srajer, R. Henning, H. Ihee, N. Purwar, J. Tenboer and S. Tripathi. Protein energy landscapes determined by five-dimensional crystallography. Acta Cryst. D Biological Crystallography 69, 2534–2542 (2013)
- R. Neutze and K. Moffat. Time-resolved structural studies at synchrotrons and X-ray free electron lasers: opportunities and challenges. Curr. Opin. Struct. Biol. 22, 651–659 (2012)
- D. Bourgeois, M. Weik. Kinetic protein crystallography: a tool to watch proteins in action. Crystallography Reviews 15 (2) 87-118 (2009) Abstract
- M. Schmidt. Structure-based kinetics by time-resolved X-ray crystallography. In Ultrashort Laser Pulses in Biology and Medicine (Markus Braun, Peter Gilch and Wolfgang Zinth, eds.), Springer Berlin Heidelberg, pp. 201-241 (2008) Abstract
- D. Bourgeois, F. Schotte, M. Brunori, and B. Vallone. Time-resolved methods in biophysics. 6. Time-resolved Laue crystallography as a tool to investigate photo-activated protein dynamics. Photochem. Photobiol. Sci. 6, 1047–1056 (2007) Abstract
- K. Moffat. Laue Crystallography: Time Resolved Studies. In International Tables for X-Ray Crystallography, Volume F: Crystallography of Biological Macromolecules, edited by M. G. Rossmann and E. Arnold. Ch. 8.2, p. 167-176 (2006) more information
- M. Schmidt, H. Ihee, R. Pahl and V. Srajer. Protein-ligand interactions probed by time-resolved crystallography. In Protein-Ligand Interactions: Methods and Applications (G. U. Nienhaus, ed.), Methods in Molecular Biology, vol. 305, Humana Press, Totawa, NJ, pp. 115-154 (2005) Abstract
- D. Bourgeois and A. Royant. Advances in kinetic protein crystallography. Current Opinion in Structural Biology 15 (5), 538-547 (2005) Abstract
- M. Goeldner, R. Givens, eds. Dynamic Studies in Biology: Phototriggers, Photoswitches and Caged Biomolecules. Wiley-VCH, pp. 410–434 (2005) Abstract
Additional Crystallography Resources
- IUCr Crystallographic Teaching Commission
- IUCr Crystallographic Education Online
- IUCr teaching pamphlets
- ACA Education Resources
- Crystallography 101
(Bernhard Rupp, q.e.d. life science discoveries) - IUCr Online Dictionary of Crystallography
- Protein crystallography course
(Randy Read, University of Cambridge) - Crystallography Tutorials
(UCLA-DOE Laboratory of Structural Biology and Molecular Medicine) - Kevin Cowtan’s resources page
(Kevin Cowtan, University of York, UK)- Book of Fourier
This is an excellent introduction to diffraction and Fourier theory with some nice images - Interactive Structure Factor Tutorial
- Book of Fourier
- Crystallography movies
(James Holton, UC Berkeley) - Interactive Tutorial about Diffraction
(Th. Proffen and R.B. Neder) - Anomalous scattering
(Ethan Merritt, University of Washington) - Merohedral Crystal Twinning Server
(Todd Yeates and Barry Fam at UCLA Department of Chemistry and Biochemistry and UCLA-DOE Laboratory of Structural Biology and Molecular Medicine) - Crystallography — CCP4 wiki